The Thromboplastin Generation Test
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چکیده
منابع مشابه
The thromboplastin generation test.
Physiological coagulation is dependent on the formation of a powerful thromboplastin within the blood. It is well recognized that coagulation defects, such as that in haemophilia, are due to a failure of the normal thromboplastin mechanism, but lack of knowledge has hitherto prevented any precise or detailed study of these abnormalities. Biggs, Douglas, and Macfarlane (1953a) have shown that th...
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Nine partial thromboplastin (cephalin) reagents have been compared in a parallel investigation of groups of patients on ;long-term' anticoagulants, a group with moderate haemophilia, and patients on heparin infusion. Results with the seven commercial reagents and a human cephalin extract have been correlated with those of a specially prepared and standardized reference preparation of human brai...
متن کاملThe effect of antibiotics on thromboplastin generation.
The effect of antibiotics on the blood coagulation mechanism has attracted the attention of many workers in various countries. Investigations have mostly been based on changes in the clotting time before, during, and after administration of the drugs in vivo (Parker and Wright, 1952; Galt and Hunter, 1950; Miller and Bass, 1952; Casassa, 1952; Macht, 1952; and many others). This approach has le...
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IN THE PRESENT investigations, it has been found that individuals with sickle cell disease (SCD) have a defective generation of thromboplastin. " 2 It is noted that this deficiency arises from an excessive loss of a labile serum factor with thrombin-like activity. MATERIALS 1. Plasma, for all testing except the serum thrombin, was prepared from whole blood anticoagulated with dry balanced oxala...
متن کاملHaemorrhagic diathesis due to a circulating anticoagulant investigated by the thromboplastin generation test.
A circulating anticoagulant which inhibits or delays the formation of thromboplastin is now a recognized cause of acquired haemorrhagic diathesis (Biggs and Macfarlane, 1953). Reported cases of this condition may be divided into three groups. The first group consists of true haemophiliacs in whom the appearance of the anticoagulant follows blood transfusion. In the second group the anticoagulan...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1953
ISSN: 0021-9746
DOI: 10.1136/jcp.6.1.23